Insulin Vial
SEMGLEE® and Insulin Glargine (insulin glargine-yfgn) injection are available as a 10 mL Vial (100 units/mL, U-100)
The following instructions are provided to patients for use. Click here for Instructions for Use.
Supplies needed for injection:
- A SEMGLEE 10 mL vial
- A U-100 insulin syringe and needle.
- Alcohol wipes.
- 1 sharps container for throwing away used needles and syringes.
Preparing the dose:
- Wash hands with soap and water or with alcohol.
- Check the vial label to make sure taking the right type of insulin. This is especially important if using more than 1 type of insulin.
- Check the insulin to make sure it is clear and colorless. Do not use SEMGLEE if it is colored or cloudy, or if particles are visible in the solution.
- Do not use SEMGLEE after the expiration date stamped on the label or 28 days after first use.
- Always use a syringe that is marked for U-100 insulin. Using a syringe other than a U-100 insulin syringe, patient may get the wrong dose of insulin.
- Always use a new syringe or needle for each injection. Do not reuse or share syringes or needles with other people. Doing so may give other people a serious infection or get a serious infection from them.
Step 1:
If using a new vial, remove the protective cap. Do not remove the
rubber stopper.

Step 2:
Wipe the top of the vial with an alcohol wipe. Do not shake the vial
of SEMGLEE before use.

Step 3:
Draw air into the syringe equal to your insulin dose. Put the needle
through the rubber top of the vial and
push the plunger to inject the air into the vial.

Step 4:
Leave the syringe in the vial and turn both upside down. Hold the
syringe and vial firmly in one hand. Make
sure the tip of the needle is in the insulin. With free hand, pull
the plunger to withdraw the correct
dose into the syringe.

Step 5:
Before taking the needle out of the vial, check the syringe for air
bubbles. If bubbles are in the syringe,
hold the syringe straight up and tap the side of the syringe until
the bubbles float to the top. Push the
bubbles out with the plunger and draw insulin back in until patient
has the correct dose.

Step 6:
Remove the needle from the vial. Do not let the needle touch
anything. Ready to inject.
Giving SEMGLEE injection:
- - Inject insulin exactly as healthcare provider has discussed.
- - Inject insulin under the skin (subcutaneously) of thigh, buttocks,
upper arms, or stomach
area
(abdomen). - - Change (rotate) injection site within the area chosen for
each dose to reduce risk
of getting pits in
the skin or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the
injection sites. - - Do not inject where the skin has pits, is thickened, or has lumps.
- - Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
Step 7:
Choose injection site. Wipe the skin with an alcohol wipe to clean
the injection site. Let the injection
site dry before injecting dose.

Step 8:
- - Pinch the skin.
- - Insert the needle in the way the healthcare provider showed.
- - Release the skin.
- - Slowly push in the plunger of the syringe all the way, making sure all the insulin has been injected.
- - Leave the needle in the skin for about 10 seconds.

Step 9:
- - Pull the needle straight out of skin.
- - Gently press the injection site for several seconds. Do not rub the area.
- - Do not recap the used needle. Recapping the needle can lead to a needle stick injury.
- - Put used needles and syringes in a FDA-cleared sharps disposal
container right away after use.
Do not
throw away (dispose of) loose needles and syringes in household trash.
- - If you do not have a FDA-cleared sharps container, use a household
container that is:
- - made of a heavy-duty plastic,
- - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
- - upright and stable during use,
- - leak resistant, and
- - properly labeled to warn of hazardous waste inside the
container.
- - When sharps disposal container is almost full, follow community
guidelines
for the right way to dispose of
sharps disposal container. There may be state or local laws about how to throw away used needles
and syringes. For more information about safe sharps disposal, and for specific information about sharps
disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
- - Do not dispose of used sharps disposal container in
household trash unless community guidelines permit
this. Do not recycle used sharps disposal container.
- - Store unused SEMGLEE vials in the refrigerator at 36° to 46°F
(2° to 8°C).
If the unopened SEMGLEE vial is stored at room temperature up to 86°F (30°C), it should be thrown
away after 28 days. - - Store in-use (opened) SEMGLEE vials in a refrigerator or at room temperature up to 86°F (30°C).
- - The SEMGLEE vials should be thrown away after 28 days, even if it still has insulin left in it.
- - Do not freeze SEMGLEE.
- - Keep SEMGLEE out of direct heat and light.
- - If a vial has been frozen or overheated, throw it away.
References:
- SEMGLEE® (insulin glargine-yfgn) injection. Prescribing Information. 2023. Biocon Biologics Inc. Cambridge, MA.
- SEMGLEE® (insulin glargine-yfgn) injection. Instructions for use. Biocon Biologics Inc. Cambridge, MA.