Insulin Prefilled Pen

SEMGLEE® and Insulin Glargine (insulin glargine-yfgn) injection are delivered through a prefilled injector pen1

  • Prefilled with 3 ml solution containing 100 U/ml insulin glargine.
  • Designed to be used for multiple subcutaneous injections with disposable needles.
  • Give patients dosing flexibility, allowing up to 80 insulin units with a single injection.

Detailed Product Pen Image and Pen Needle Image

How to use SEMGLEE prefilled syringe2
Click here for Instructions for Use

Step 1. Check the insulin

  1. Check the label on your SEMGLEE to make sure you have the correct insulin. SEMGLEE is blue with a purple injection button.
  2. Take off the pen cap.
  3. Check the appearance of your insulin. SEMGLEE is a clear insulin. Do not use this SEMGLEE if the insulin is cloudy, colored or has particles.

Step 2. Attach the needle

Do not re-use needles. Always use a new sterile needle for each injection. This helps prevent contamination and potential needle blocks.

  1. Wipe the rubber seal with alcohol.
  2. Remove the protective seal from a new needle.
  3. Line up the needle with the pen, and keep it straight as you screw it on (See Figure below).

    Hand Lining Up Needle to Pen

  • If the needle is not kept straight while you attach it, it can damage the rubber seal and cause leakage, or break the needle (See Figure below).
    Hand Misaligning Needle to Pen

Step 3. Perform a Safety test
Always perform the safety test before each injection.
Performing the safety test ensures that you get an accurate dose by:

  •  ensuring that pen and needle work properly
  •  removing air bubbles
  1. Select a dose of 2 units by turning the white dose knob (See Figure below).
    Hand Turning Dial Clockwise by 2 Units
  2. Take off the outer needle cap and keep it to remove the used needle after injection. Take off the inner needle cap and discard it (See Figure below).
    Removal of Cap Leaving Needle Attached to Pen
  3. Hold the pen with the needle pointing upwards.
  4. Tap the cartridge so that any air bubbles rise up towards the needle.
  5. Press the purple injection button all the way in. Check if insulin comes out of the needle tip (See Figure below).
    Pen with Insulin Droplets

You may have to perform the safety test several times before insulin is seen.

  • If no insulin comes out, check for air bubbles and repeat the safety test two more times to remove them.
  • If still no insulin comes out, the needle may be blocked. Change the needle and try again.
  • If no insulin comes out after changing the needle, your SEMGLEE may be damaged. Do not use this SEMGLEE.

Step 4. Select the dose

You can set the dose in steps of 1 unit, from a minimum of 1 unit to a maximum of 80 units. If you need a dose greater than 80 units, you should give it as two or more injections.

  1. Check that the dose window shows “0” following the safety test.
  2. Select your required dose (in the example below, the selected dose is 30 units, see Figure below). If you turn past your dose, you can turn back down.
    Hand Turning Dial Clockwise by 2 Units
  • Do not push the purple injection button while turning, as insulin will come out.
  • You cannot turn the white dose knob past the number of units left in the pen. Do not force the dosage selector to turn. In this case, either you can inject what is remaining in the pen and complete your dose with a new SEMGLEE or use a new SEMGLEE for your full dose.

Step 5. Inject the dose

  1. Use the injection method as instructed by your healthcare professional.
  2. Insert the needle into the skin (See Figure below).
    Pen Being Inserted into Skin
  3. Deliver the dose by pressing the purple injection button in all the way. The number in the dose window will return to “0” as you inject. The white dose knob will turn, and you will hear “clicks” as you press down (See Figure below).
    Thumb Holding Purple Injection Button for 10 Seconds
  4. Keep the purple injection button pressed all the way in. Slowly count to 10 before you withdraw the needle from the skin. This ensures that the full dose will be delivered.

Step 6. Remove and discard the needle

Always remove the needle after each injection and store SEMGLEE without a needle attached.
This helps prevent:

  • Contamination and/or infection
  • Entry of air into the insulin cartridge and leakage of insulin, which can cause inaccurate dosing.
  1. Put the outer needle cap back on the needle, and use it to unscrew the needle from the pen. To reduce the risk of accidental needle injury, never replace the inner needle cap.
    • If your injection is given by another person, special caution must be taken by this person when removing and disposing the needle. Follow recommended safety measures for removal and disposal of needles (e.g., a one-handed capping technique) in order to reduce the risk of accidental needle injury and transmission of infectious diseases.
  2. Dispose of the needle safely. Used needles should be placed in sharps containers (such as red biohazard containers), hard plastic containers (such as detergent bottles), or metal containers (such as an empty coffee can). Such containers should be sealed and disposed of properly. If you are giving an injection to another person, you should remove the needle in an approved manner to avoid needle-stick injuries.
  3. Always put the pen cap back on the pen, then store the pen until your next injection.

References:

  • SEMGLEE® (insulin glargine-yfgn) injection. Prescribing Information. 2023. Biocon Biologics Inc. Cambridge, MA. 
  • SEMGLEE® (insulin glargine-yfgn) injection. Instructions for use. Biocon Biologics Inc. Cambridge, MA.